Diseases and Treatments

338- Bone Marrow Aplasia Treatment ,Bone Marrow Aplasia

Bone Marrow Aplasia Treatment. People rarely think about their bones. Eating protein, iron, and B vitamins will help bone marrow do its job.

Bone Marrow Aplasia Treatment
Bone Marrow Aplasia Treatment

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Bone Marrow Aplasia Treatment

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Bone Marrow Aplasia Treatment


Bone Marrow Aplasia Treatment. Bone Marrow Aplasia is the vanishing of the cells responsible for blood production in the bone marrow. As result, there is a diminution of red blood cells (RBC), white blood cells (WBC), and platelets in the peripheral blood. Medullary aplasia can be:

  • Total, when it affects the cells that produce red blood cells, leukocytes,s and platelets.
  • Partial, if only one or two of the cell lines are affected.

Symptoms of bone marrow aplasia: Bone Marrow Aplasia TreatmentThe ailment of bone marrow aplasia is determined by the degree of involvement of each of the elements that make up blood. As soon as the production of red blood cells (erythrocytes) is compromised, anemia will appear with its accompanying symptoms of paleness, asthenia, headaches, palpitations, shortness of breath, dizziness, cramps, etc. If the production of white blood cells (leukocytes) is also altered, the patient will have an exaggerated tendency to suffer from infections, usually caused by rare germs. In the end, if the production of platelets is compromised, the presence of hemorrhages will be frequent, which may be slight (epistaxis, gingivorrhages) or may compromise the life of the patient (digestive or cerebral hemorrhages).

 most common symptoms

  • Anemia.
  • Tendency to suffer from infections.
  • Bleeding.


 Causes of bone marrow aplasia:

Bone marrow aplasia is an acquired disease. The most frequent agents in its development are infections (mainly viral), drugs,s and environmental toxic agents (benzol, paints, varnishes, insecticides, etc.).

However, often the cause of the disease cannot be identified (these are the cases known as idiopathic).

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 The prognosis for bone marrow aplasia: Bone Marrow Aplasia Treatment

The main prognostic factor for medullary aplasia is the degree of bone marrow involvement. Likewise, the prognosis is conditioned by the number of complications that can occur during the evolution of the disease.

Although until a few years ago the prognosis, especially of severe forms, was relatively poor, at present it has improved with the performance of allogeneic bone marrow transplantation.

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Marrow aplasia diagnosis: We diagnosed Bone marrow through the hemogram. A diminution in the number of red blood cells, leukocytes, and platelets is observed. When cells are observed under the microscope, they are morphologically normal. Given these results, it is essential to carry out a study of the bone marrow (biopsy), in which a total or partial absence of the cells responsible for producing the blood elements will be observed. In addition, this study will allow differentiation of other hematological processes that can also occur with anemia, leukopenia, and/or thrombopenia, as is the case of acute leukemias. Click below to order clove oil

Marrow aplasia treatment: Bone Marrow Aplasia Treatment

  • Treatment of medullary aplasia

Specific treatment of the disease should be carried out according to the severity of the medullary aplasia. To alleviate the decrease in leukocytes, infectious diseases should be prevented by administering antibiotics and extreme aseptic measures. Young patients with acute aplasia should undertake bone marrow transplantation when an appropriate donor is found. Other treatments that can be administered, if no donor is available, are anti-infective or anti-mycotic globulin, corticoids, cyclosporine A, etc. When aplasia is not acute or the patient is not old enough to undergo a bone marrow transplant, in addition to supportive treatment, hematopoietic growth factors (which stimulate the production of cells by the bone marrow) or immunoglobulins may be administered.

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Foods That Strengthen Bone Marrow

People rarely think about their bones, much less what’s inside them. Without healthy bone marrow, your body can’t make the white and red blood cells that support oxygen transportation, blood clotting, and a strong immune system. Eating protein, iron, and B vitamins will help bone marrow do its job

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Bone Marrow Basics: Bone Marrow Aplasia Treatment

Marrow is a spongy material found inside most of the bones in the body. It contains stem cells that develop into red and white blood cells and platelets. Each type of blood cell has an important function:

  • Red blood cells transport oxygen throughout the body.
  • White blood cells support the immune system to fight infection.
  • Platelets are required for proper blood clotting.

There are two types of white blood cells:

  • Neutrophils and macrophages fight bacterial and fungal infections by consuming germs.
  • Lymphocytes fight fungal, viral, and bacterial infections. T lymphocytes, or T cells, attack germs.

Bone contains two different types of marrow: red and yellow. Red marrow contains the stem cells that become red and white blood cells and platelets, while yellow marrow is comprised primarily of fat.

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Read more: Become Father with Kallmann Syndrome

Protein-Packed Bone Marrow Foods: Bone Marrow Aplasia Treatment

Protein is a component of all your body’s cells and tissues your organs, bones, muscle, fat and connective tissue. It’s even part of your blood, which is considered a connective tissue. A protein deficiency can compromise bone marrow health and the production of healthy blood cells, according to a study published in the journal ​PLOS One​ in March 2013.

The Food and Nutrition Board of the National Academies of Medicine has set a recommended daily intake of protein of 46 grams per day for people assigned female at birth (AFAB) and 56 grams per day for people assigned male at birth (AMAB). These estimates are based on an average of 0.8 grams per kilogram of body weight. Whether you are AMAB or AFAB, if you weigh 155 pounds, you need about 56 grams daily. During pregnancy and lactation, aim for around 71 grams daily.

The best sources of protein are lean meats, poultry without skin, fish, beans, lentils, yogurt, milk, eggs, nuts, and seeds. Some examples of the amounts of protein in one serving of these blood-building foods, according to Johns Hopkins Medicine, include:

Protein Food

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  • 3 ounces of beef, chicken, turkey, pork, and lamb: 21 grams
  • 3 ounces of tuna fish: 21 grams
  • One egg: 6 grams
  • One-half cup lentils: 9 grams
  • One-half cup of black, kidney, and navy beans: 8 grams
  • 3 ounces of tofu: 9 grams
  • 1 ounce of nuts: 4 to 6 grams
  • 5 ounces of nonfat Greek yogurt: 12 to 18 grams
  • One-half cup cottage cheese: 14 grams
  • One-third cup quinoa: 6 grams

These lean and healthy sources of protein also come packed with other nutrients you need to strengthen bone marrow.

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Read more: Become Father with Kallmann Syndrome

Vitamins for Bone Marrow Health:

Getting adequate amounts of all 13 essential vitamins is crucial for healthy bone marrow. But some of the B vitamins play an especially important role in supporting healthy red blood cell production.

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Both vitamin B12 and folic acid, or B9, help the body make red blood cells to carry oxygen throughout the body. A deficiency in either of these nutrients leads to a condition called anemia. With vitamin B12 deficiency anemia, the body can’t make enough red blood cells. With folate deficiency anemia, the body produces fewer red blood cells, and those it does produce are abnormally large and misshapen. They also may die more quickly than healthy red blood cells.

Symptoms of the two conditions are similar, reports the National Institutes of Health (NIH):

  • Fatigue
  • Weakness
  • Shortness of breath
  • Irritability
  • Tender and smooth tongue
  • Diarrhea
  • Decreased appetite
  • Heart palpitations

Other symptoms of B12 anemia may include:

  • Dizziness
  • Neurological changes
  • Numbness and tingling in the hands and feet
  • Poor balance
  • Depression
  • Confusion
  • Dementia
  • Memory problems

The daily recommended intake for B12 for adults is 2.4 micrograms, 2.6 micrograms for pregnant people, and 2.8 micrograms for people who are breastfeeding, according to the NIH. B12 is found naturally only in animal foods, but some plant foods are fortified with nutrients. The best sources include:

  • Cooked clams: 84.1 micrograms per 3 ounces
  • Beef liver: 70.7 micrograms per 3 ounces
  • Cooked wild rainbow trout: 5.4 micrograms per 3 ounces
  • Cooked sockeye salmon: 4.8 micrograms per 3 ounces
  • Canned light tuna fish: 2.5 micrograms per 3 ounces
  • Fortified breakfast cereal: 1.5 micrograms per serving
  • Low-fat milk: 1.2 micrograms per cup

The recommended intake for folate for adults is 400 micrograms, 600 micrograms for pregnant people, and 500 micrograms for people who are breastfeeding, according to the NIH.

Folate is found abundantly in plant foods, such as:

  • Boiled spinach: 131 micrograms per one-half cup
  • Boiled black-eyed peas: 105 micrograms per one-half cup
  • Fortified breakfast cereals: 100 micrograms per serving
  • Boiled asparagus: 89 micrograms in four spears
  • Boiled frozen Brussels sprouts: 78 micrograms in one-half cup
  • Cooked white rice: 54 micrograms in one-half cup

Read more: Become Father with Kallmann Syndrome

Iron and Red Blood Cells:

The mineral iron is an essential part of hemoglobin, a red blood cell protein that transports oxygen from the lungs to all the tissues in the body. Dietary iron is used by the bone marrow to create red blood cells, and an iron deficiency can result in anemia.

Iron deficiency anemia has symptoms similar to those of folate and B12 deficiency anemias:

  • Fatigue
  • Weakness
  • Sore tongue
  • Dizziness
  • Shortness of breath

Additional symptoms specific to iron deficiency anemia include:

  • Sensitivity to cold
  • Restless leg syndrome
  • Pica a desire to chew ice or non-food items, including dirt
  • Loss of interest in work, relationships, recreation, and intimacy

People with AMAB need 8 milligrams of iron each day, but people with AFAB have different daily iron needs at different life stages. Before menopause, they need 18 milligrams of iron each day to account for blood loss during menstruation. After menopause, those needs decrease to 8 milligrams daily. During pregnancy, iron needs greatly increase to 27 milligrams; during lactation, they drop to 9 milligrams.

Foods contain two types of iron heme iron found in animal foods and non-heme iron found in plant foods. Heme iron is more bioavailable than non-heme iron. In addition, its absorption is less affected by other dietary components. For example, the non-heme iron in spinach may be poorly absorbed because it contains plant chemicals called polyphenols that inhibit iron absorption.

According to NIH, sources of heme iron include:

  • Cooked oysters: 8 milligrams in 3 ounces
  • Pan-fried beef liver: 5 milligrams in 3 ounces
  • Sardines canned in oil: 2 milligrams
  • Braised beef: 2 milligrams in 3 ounces

Non-heme iron can be found in:

  • Canned white beans: 8 milligrams per cup
  • Dark chocolate: 7 milligrams in 3 ounces
  • Boiled lentils: 3 milligrams per one-half cup
  • Firm tofu: 3 milligrams per one-half cup

NIH reports that approximately 14 to 18 percent of iron in a mixed diet containing plant and animal foods is bioavailable, while vegetarian diets may provide 5 to 12 percent of bioavailable iron. If you eat a strict vegetarian diet, talk to your doctor about whether you are getting enough iron to support healthy red blood cell production.

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